en / es /
PANEL OWLiver® About OWLiver® UHPLC-MS PROGRESSION OF HEPATIC DISEASE Clinical practice Sample collection
Non-invasive diagnostics

PANEL
OWLiver®

OWLiver® Panel: A non-invasive diagnostic tool for assessing all lesional phases of MAFLD (Metabolic Dysfunction-Associated Fatty Liver Disease). This lipidomic analysis of fasting blood samples uses high-resolution liquid chromatography coupled with mass spectrometry (UHPLC-MS) to measure a panel of lipid biomarkers reflecting liver fat content, inflammation, and fibrosis.

Scroll down
metabolomics testing
Non-invasive diagnostics

About
OWLiver®

Developed by Rubió Metabolomics, S.L.U., the OWLiver® Panel is a CE-marked in vitro diagnostic medical device, complying with Directive 98/79/EC. Its three algorithms includes lipid concentrations and clinical data, providing an estimation of MAFLD stage based on a multicenter, multiethnic study involving patients affected by different severity of type 2 diabetes mellitus and a body mass index above 25 kg/m2.

Progression of Hepatic Disease
Interactive by OWL Metabolomics by Rubió

Healthy Liver HEPATIC STEATOSIS STEATOHEPATITIS WITH FIBROSIS (F0-F1) STEATOHEPATITIS WITH FIBROSIS (F≥2)

HEALTHY LIVER

Less than 5% of liver cells contain fat.
Reddish brown color with uniform texture.
Average weight between 1400 and 1800 grams.
The liver is significantly reduced in size and appears brownish in color.
In addition to fat, inflammation and liver cell damage, scar tissue increases.
Fibrosis leads to loss of elasticity and liver function.
It significantly increases the risk of death from cardiovascular disease.
Between 10-15% of people with steatohepatitis progress to cirrhosis.
In patients with F4 there is a high risk of developing end-stage liver diseases, such as liver cancer.

HEPATIC STEATOSIS

More than 5% of liver cells contain fat.
The liver takes on a mottled, soft, pale yellow appearance and increases in size.
Approximately 25-30% of the world’s population has hepatic steatosis.
In people with obesity or type 2 diabetes mellitus, the incidence increases to 70%.

STEATOHEPATITIS WITH FIBROSIS (F0-F1)

Between 15-20% of people with hepatic steatosis develop steatohepatitis.
Inflammatory infiltrates and liver cell damage (ballooning) are observed.
Fibrosis or scarring begins to appear.
The risk of death from cardiovascular disease increases.

STEATOHEPATITIS WITH FIBROSIS (F≥2)

The liver is significantly reduced in size and appears brownish in color.
In addition to fat, inflammation and liver cell damage, scar tissue increases.
Fibrosis leads to loss of elasticity and liver function.
It significantly increases the risk of death from cardiovascular disease.
Between 10-15% of people with steatohepatitis progress to cirrhosis.
In patients with F4 there is a high risk of developing end-stage liver diseases, such as liver cancer.
Best practices guidelines

SAMPLE COLLECTING AND SHIPMENT

1
Blood collection
Blood collection
2
Serum collection
Serum collection
3
Storage
Storage
4
Transport
Transport
5
De-frosting
De-frosting
6
Processing
Processing
7
Report
Report
Cookies
We use our own and third-party cookies to be able to correctly offer you all the functionalities of the website, for analytical purposes and to show you personalized advertising according to a profile prepared from your browsing habits. You can accept all cookies by clicking "Accept cookies", obtain more information in our" Cookie policy or configure them or reject their use by clicking on Configuration.".
Accept Cookies Configure
Basic cookie information
This website uses cookies and/or similar technologies that store and retrieve information when you browse. In general, these technologies can serve very different purposes, such as, for example, recognizing you as a user, obtaining information about your browsing habits or customizing the way in which the content is displayed. The specific uses we make of these technologies are described below. By default, all cookies are disabled, except for the technical ones, which are necessary for the website to work. If you wish to expand the information or exercise your data protection rights, you can consult our Cookies Policy.".
Accept cookies Manage preferences
Technical and/or necessary cookies Always active
Technical cookies are those that facilitate user navigation and the use of the different options or services offered by the web such as identifying the session, allowing access to certain areas, facilitating orders, purchases, filling in forms, registration, security, facilitating functionalities. (videos, social networks…).
Analysis cookies
Analysis cookies are those used to carry out anonymous analysis of the behavior of web users and that allow user activity to be measured and navigation profiles to be created with the objective of improving websites.
Confirm preferences
Linkedin Twitter
By Rubió
Carrer Indústria 29, Polígon Industrial Comte de Sert 08755
Castellbisbal, Barcelona (España), +34 937 722 509labrubio@labrubio.com
Popupcontent
Accept